Molecular evolution and structural analyses of the spike glycoprotein from Brazilian SARS-CoV-2 genomes: the impact of selected mutationsArticle Published on 2023-04-012023-07-09 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] COVID-19 Infectious diseases molecular evolution Positive selection severe acute respiratory syndrome coronavirus 2 Spike. [DOI] 10.1080/07391102.2022.2076154 PMC 바로가기
Evolutionary Pattern Comparisons of the SARS-CoV-2 Delta Variant in Countries/Regions with High and Low Vaccine CoverageArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerate caused Cluster co-mutation Coverage COVID-19 vaccine Delta delta variant dominant exhibited FIVE Frequency G142D Genetic genetic divergence genetic diversity Host immune immune evasion immune pressure Infection less Methylation Mutation ORF7a pattern Positive selection proportion SARS-CoV-2 sequence suggested the S protein the SARS-CoV-2 unique Vaccine vaccine coverage. variant Variation [DOI] 10.3390/v14102296 PMC 바로가기
Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humansArticle Published on 2022-10-132023-06-22 Journal: Cell [Category] 조류인플루엔자, [키워드] arms race arteriviruses CD163 receptor disease emergence hemorrhagic fever Positive selection primates virus entry Virus evolution zoonosis. [DOI] 10.1016/j.cell.2022.09.022 PMC 바로가기
Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and MinksArticle Published on 2022-09-012022-11-16 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] adaptive amino acid changes analyzed change circulating deviate domain early phase Epidemic Epidemics Evolution feature Frequency Genetic genetic hitchhiking Host Human humans Infection Ka/Ks lack late phase mink Mutation mutations Neutral nonsynonymous other coronaviruses outbreak pandemic parental pattern positive Positive selection produced receptor-binding motif SARS-CoV SARS-CoV-2 selection process sequence site frequency spectrum site frequency spectrum. Stage Strong synonymous the SARS-CoV-2 the spike protein unique variant virus virus [DOI] 10.1093/molbev/msac156 PMC 바로가기
Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19박쥐와 영장류에서 SARS-CoV-2 상호작용 단백질의 뚜렷한 진화 궤적은 COVID-19의 중요한 숙주 결정 요인을 식별합니다Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation adaptive analysis Arm arms race autophagy bat bats caused clinical trial comparative genetics coronavirus coronavirus coronavirus disease COVID-19 COVID-19 severity detection determinant Epidemics functional FYCO1 Genes Genetic genetic determinant Genome genomes Host humans identify in vivo Inflammation Inflammatory involved loci mammalian occurred pandemic Pathogenesis performed Phosphorylation positive Positive selection primates primates and bats Protein Regulation Replication residue residues RIPK1 SARS-CoV SARS-CoV-2 SARS-CoV-2 and COVID-19 SARS-COV-2 infection SARS-CoV-2 susceptibility severe acute respiratory syndrome Coronavirus severe COVID-19 severity signature susceptibility targets TMPRSS2 trajectory Vaccines virus virus–host coevolution. [DOI] 10.1073/pnas.2206610119 PMC 바로가기 [Article Type] Article
Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from ChinaArticle Published on 2022-08-292022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] adaptive addition America Analysis analyzed Asia Bayesian Bayesian inference caused Characteristics China coronavirus COVID-19 epidemic Cross-species transmission distribution Dynamics event Evolution evolutionary dynamics finding genetic diversity Genome sequence data genotypes highlighting Human humans infect likelihood lineages maximum measure membrane fusion Migration Pandemics PDCoV phylogeography phylogeography. Porcine deltacoronavirus Positive selection recent Sample spatiotemporal Spike protein Surveillance Suspected TGEV transmissible gastroenteritis virus Transmission transmission rate transmitted [DOI] 10.3390/ijms23179786 PMC 바로가기
“Is Omicron mild”? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies"오미크론은 마일드한가"? 세 계보의 돌연변이 환경과 기존 백신 및 치료 항체에 대한 반응으로 이 내러티브 테스트Review Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody conserved convalescent COVID-19 infections Effectiveness Evolution Genome Giant immune immune evasion Immunity infections Lineage mild symptoms monoclonal Mutation narrative neutralization neutralization resistance Neutralizing antibodies neutralizing antibody omicron Omicron lineages Pathogenesis polyclonal Positive selection produced raised Receptor-binding domain reduction in Reinfection reported SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants shown Spike protein tested Testing the receptor-binding domain the spike protein therapeutic triggered Vaccine vaccine effectiveness (VE) Viral viral evolution viral evolution. virus infectivity [DOI] 10.1002/jmv.27749 PMC 바로가기 [Article Type] Review
Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility종 내 및 종 간 SARS-CoV-2 전염성 예측 모델Article Published on 2022-07-192022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 complex Coronaviridae Coronaviridae family coronavirus enzyme expected feature host receptor hosts human ACE2 receptor humans in silico infect Infection interact interfacing residues Model Mutation pandemic Positive selection positively correlated predict predicted Prediction model Protein receptor complex replacement reported reservoir residue residues S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants shown species spike spike glycoprotein spike glycoprotein (S). subtype Subtypes susceptible the Coronaviridae the SARS-CoV-2 thought Transmissibility transmissibility of SARS-CoV-2 virus [DOI] 10.3390/v14071565 PMC 바로가기 [Article Type] Article
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infectionSARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향Article Published on 2022-05-242022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses [DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment Research Published on 2022-04-252022-10-05 Journal: Nature Microbiology [Category] 변종, 유전자 메커니즘, [키워드] A. fumigatus acquisition Analysis Aspergillus fumigatus biosynthetic canonical caused clade defined driver drug resistance drug-resistant drugs fungal genes encoding Genetic Genomic analysis Genotype Human increasingly Infection Ireland isolate isolates loci majority numbers of patient Occurrence pathogen pathway Patient population genomics Positive selection Recombination Region resistance mechanisms second selective sweep susceptible susceptible patient transmitted understanding viral respiratory [DOI] 10.1038/s41564-022-01091-2 [Article Type] Research